Blood vessels and inflammation in Alzheimer’s

Scientists in Bath, U.K. are investigating blood vessel damage in the brain during Alzheimer’s and whether amyloid, a hallmark Alzheimer’s protein, may play a role in this damage. Damage to blood vessels has been observed in the brain during Alzheimer’s and evidence suggests that Alzheimer’s patients are at greater risk of cardiovascular diseases such as stroke. Amyloid is present in blood and in some cases can accumulate in blood vessels, causing problems. It may cause platelets to behave abnormally, making them more likely to clot and increasing the risk of strokes and haemorrhages in the brain. It is therefore important to investigate why blood vessel damage occurs and the role of amyloid to find ways to protect against, and reduce the risk of, cardiovascular problems in Alzheimer’s. Preventing blood vessel damage in Alzheimer’s could help slow the progression of the disease and reduce the health complications that can be an added burden to someone with Alzheimer’s.