NIH-supported study shows promise for blood test for Alzheimer’s disease

August 15, 2014

Preliminary findings from a study by National Institute on Aging (NIA), scientists and colleagues showed that a blood test for Alzheimer’s-related proteins may accurately predict who might be at risk for the disease years before symptoms develop. The test measured the levels of several tau and amyloid proteins—the hallmarks of Alzheimer’s disease—in exosomes, microscopic organelles shed by brain cells.

Compared to those free of the disorder, the blood test showed people with Alzheimer’s had higher elevations of three proteins (p-5396-tau, p-181 tau, and Ab42) in exosomes. The test was 96 percent accurate in distinguishing between these two groups. Significantly, the investigators also found elevated levels of these proteins in blood samples collected from cognitively healthy older people who later developed dementia within one to ten years.

Courtesy: National Institute on Aging (NIA), United States